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Peripheral blood mononuclear cells exhibit increased mitochondrial respiration after adjuvant chemo- and radiotherapy for early breast cancer.

Ida Bager ChristensenMarie-Louise AbrahamsenLucas RibasKristian Buch-LarsenDjordje MarinaMichael AnderssonSteen LarsenPeter SchwarzFlemming DelaLinn Gillberg
Published in: Cancer medicine (2023)
This study shows that mitochondrial respiration and mtDNA content in circulating PBMCs increase after adjuvant chemo- and radiotherapy in postmenopausal patients with EBC. Besides the increased mtDNA content, a shift in PBMC subpopulation proportions towards cells relying on oxidative phosphorylation, who may be less sensitive to chemotherapy, might influence the increased mitochondrial respiration observed iafter chemotherapy.
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