Peripheral blood mononuclear cells exhibit increased mitochondrial respiration after adjuvant chemo- and radiotherapy for early breast cancer.
Ida Bager ChristensenMarie-Louise AbrahamsenLucas RibasKristian Buch-LarsenDjordje MarinaMichael AnderssonSteen LarsenPeter SchwarzFlemming DelaLinn GillbergPublished in: Cancer medicine (2023)
This study shows that mitochondrial respiration and mtDNA content in circulating PBMCs increase after adjuvant chemo- and radiotherapy in postmenopausal patients with EBC. Besides the increased mtDNA content, a shift in PBMC subpopulation proportions towards cells relying on oxidative phosphorylation, who may be less sensitive to chemotherapy, might influence the increased mitochondrial respiration observed iafter chemotherapy.
Keyphrases
- locally advanced
- early stage
- rectal cancer
- oxidative stress
- radiation therapy
- squamous cell carcinoma
- early breast cancer
- induced apoptosis
- mitochondrial dna
- copy number
- photodynamic therapy
- cancer therapy
- radiation induced
- cell cycle arrest
- gene expression
- cell death
- bone mineral density
- drug delivery
- cell proliferation
- chemotherapy induced
- breast cancer risk