Identification of TIE2 as a susceptibility gene for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.
Zhen Ji ChenLi MaMarten E BrelenHaoyu ChenMotokazu TsujikawaTimothy Y LaiMary HoKaori SayanagiChikako HaraNoriyasu HashidaPancy Os TamAlvin L YoungKohji NishidaClement Chee Yung ThamChi Pui PangGuy L J ChenPublished in: The British journal of ophthalmology (2020)
This study revealed TIE2 as a novel susceptibility gene for nAMD and PCV in Japanese and Chinese. Further studies in other populations are warranted to confirm its role.