Single-Cell Transcriptional Signatures of Glomerular Disease in Transgenic Mice with APOL1 Variants.

Teruhiko Yoshida Khun Zaw LattBriana A SantoShashi ShrivastavYongmei ZhaoParide FenaroliJoon-Yong ChungStephen M HewittVincent M TutinoPinaki Sarder Avi Z Rosenberg Cheryl A Winkler Jeffrey B Kopp

Published in: Journal of the American Society of Nephrology : JASN (2024)

These findings in two mouse models demonstrated both shared and distinct cell type-specific transcriptomic signatures induced by APOL1 variants. These findings suggest novel therapeutic opportunities for APOL1 glomerulopathies.

Keyphrases

single cell
copy number
rna seq
genome wide
mouse model
gene expression
high throughput
transcription factor
diabetic nephropathy
endothelial cells
oxidative stress
heat shock