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Single-Cell Transcriptional Signatures of Glomerular Disease in Transgenic Mice with APOL1 Variants.

Teruhiko YoshidaKhun Zaw LattBriana A SantoShashi ShrivastavYongmei ZhaoParide FenaroliJoon-Yong ChungStephen M HewittVincent M TutinoPinaki SarderAvi Z RosenbergCheryl A WinklerJeffrey B Kopp
Published in: Journal of the American Society of Nephrology : JASN (2024)
These findings in two mouse models demonstrated both shared and distinct cell type-specific transcriptomic signatures induced by APOL1 variants. These findings suggest novel therapeutic opportunities for APOL1 glomerulopathies.
Keyphrases
  • single cell
  • copy number
  • rna seq
  • genome wide
  • mouse model
  • gene expression
  • high throughput
  • transcription factor
  • diabetic nephropathy
  • endothelial cells
  • oxidative stress
  • heat shock