Microstructural fronto-striatal and temporo-insular alterations are associated with fatigue in patients with multiple sclerosis independent of white matter lesion load and depression.
Miklos PalotaiMichele CavallariIsmail KoubiyrAlfredo Morales PinzonAria NazeriBrian C HealyBonnie GlanzHoward L WeinerTanuja ChitinisCharles Rg GuttmannPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2019)
Damage to ventromedial prefronto-precommissuro-striatal and temporo-insular pathways appears to be a specific substrate of SF in MS.