Increased Risk of Valvular Heart Disease in Systemic Sclerosis: An Underrecognized Cardiac Complication.
Reto D KurmannEdward A El-AmYasser A RadwanAvneek S SandhuCynthia S CrowsonEric L MattesonKenneth J WarringtonRekha MankadAshima MakolPublished in: The Journal of rheumatology (2021)
Patients with SSc have a 4-fold increase in the prevalence of moderate/severe VHD at diagnosis compared to non-SSc patients. They also have a 4-fold increased risk of developing moderate/severe VHD after diagnosis of SSc. Aortic stenosis and mitral regurgitation have a much higher prevalence in patients with SSc, besides secondary tricuspid regurgitation. Underlying mechanisms for this association require further elucidation.
Keyphrases
- aortic stenosis
- ejection fraction
- systemic sclerosis
- aortic valve
- aortic valve replacement
- transcatheter aortic valve replacement
- left ventricular
- transcatheter aortic valve implantation
- interstitial lung disease
- end stage renal disease
- risk factors
- early onset
- chronic kidney disease
- coronary artery disease
- newly diagnosed
- pulmonary hypertension
- high intensity
- peritoneal dialysis
- prognostic factors
- heart failure
- patient reported outcomes
- rheumatoid arthritis
- patient reported