Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway.
Orlei Ribeiro de AraújoReinaldo SalomãoMilena Karina Coló BrunialtiDafne Cardoso Bourguignon da SilvaAndreza Almeida SenerchiaFabianne Altruda de Moraes Costa CarlesseAntonio Sergio PetrilliPublished in: Mediators of inflammation (2017)
Cytokines kinetics showed proinflammatory and anti-inflammatory responses similar to what is described in nonneutropenic patients. IL-8, IL-6, IL-10, and procalcitonin are useful as early biomarkers of sepsis. Filgrastim upregulates expression of these markers, and we observed deficiency in the IL-23-IL-17 axis accompanying sepsis.