Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation.
Wenlong ShangGuilin ChenYinxiu LiYujuan ZhuoYuhong WangZhicai FangYing YuHuiwen RenPublished in: Journal of diabetes research (2019)
Impaired wound healing is commonly encountered in patients with diabetes mellitus, which may lead to severe outcomes such as amputation, if untreated timely. Macrophage plays a critical role in the healing process including the resolution phase. Although magnetic therapy is known to improve microcirculation, its effect on wound healing remains uncertain. In the present study, we found that 0.6 T static magnetic field (SMF) significantly accelerated wound closure and elevated reepithelialization and revascularization in diabetic mice. Notably, SMF promoted the wound healing by skewing the macrophage polarization towards M2 phenotype, thus facilitating the resolution of inflammation. In addition, SMF upregulated anti-inflammatory gene expression via activating STAT6 and suppressing STAT1 in macrophage. Taken together, our results indicate that SMF may be a promising adjuvant therapeutic tool for treating diabetic wounds.
Keyphrases
- wound healing
- gene expression
- oxidative stress
- anti inflammatory
- single molecule
- signaling pathway
- cell proliferation
- dna methylation
- early stage
- type diabetes
- percutaneous coronary intervention
- stem cells
- early onset
- metabolic syndrome
- coronary artery bypass grafting
- acute coronary syndrome
- mesenchymal stem cells
- atrial fibrillation
- lower limb
- cell therapy