Amino acid-based H2S donors: N-thiocarboxyanhydrides that release H2S with innocuous byproducts.

Kuljeet Kaur Patrick Enders Yumeng Zhu Abigail F BrattonChadwick R PowellKhosrow Kashfi John B Matson

Published in: Chemical communications (Cambridge, England) (2021)

A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H2S-release kinetics is reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing donors exhibiting the greatest cytotoxic effects.

Keyphrases

amino acid
drinking water
oxidative stress
liver failure
kidney transplantation
preterm infants
respiratory failure
drug induced
aortic dissection
gestational age
intensive care unit
acute respiratory distress syndrome