Recombinant Human PH20: Baseline Analysis of the Reactive Antibody Prevalence in the General Population Using Healthy Subjects.
Sanna RosengrenJennifer SourathaDave ConwayDouglas B MuchmoreBarry J SugarmanPublished in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy (2018)
Approximately 1/20 of the adult population had rHuPH20-reactive antibodies. The reason remains unknown; however, no evidence for a negative effect on fertility or association with autoimmune disease was demonstrated.