Stool interleukin-1β differentiates Clostridioides difficile infection from asymptomatic carriage and non-C.difficile infection diarrhea.
Javier A Villafuerte GálvezNira R PollockCarolyn D AlonsoXinhua ChenHua XuLamei WangNicole WhiteAlice BanzMark MillerKaitlyn DaughertyAnne J Gonzalez-LunaCaitlin BarrettRebecca SpragueKevin W GareyCiaran P KellyPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
Stool concentrations of the inflammasome pathway, pro-inflammatory cytokine IL-1β can accurately differentiate CDI from asymptomatic carriage and non-CDI diarrhea, making it a promising biomarker for CDI diagnosis. Significant positive correlations exist between stool toxins and stool IL-1β in CDI but not in asymptomatic carriers.