Recurrence of primitive germ cell tumour 20 years on.
Helen-Cara YounanGeorgina KeoghMichael SecklNaveed SarwarPublished in: BMJ case reports (2023)
We present a case of a woman in her 20s, with a prior history of paediatric sacrococcygeal germ cell tumour, presenting with a 6-month history of perianal pain. An MRI pelvis revealed a heterogeneous soft tissue mass causing destruction of the sacrococcygeal bone. A staging CT demonstrated metastatic deposits in the lungs and hypodense foci in the liver suspicious of metastatic disease. Her alpha-fetoprotein levels were raised and a CT-guided biopsy was in keeping with recurrent germ cell tumour. She was referred to a national centre for the treatment of germ cell tumours in adults and was rechallenged with cisplatin-based multiagent chemotherapy with a curative intent. This case raises the important question of how long we should follow-up these patients and whether they can ever be safely discharged from oncology surveillance.
Keyphrases
- germ cell
- contrast enhanced
- soft tissue
- end stage renal disease
- squamous cell carcinoma
- small cell lung cancer
- computed tomography
- magnetic resonance imaging
- image quality
- prognostic factors
- newly diagnosed
- chronic kidney disease
- ejection fraction
- dual energy
- chronic pain
- emergency department
- intensive care unit
- lymph node
- case report
- pain management
- peritoneal dialysis
- quality improvement
- positron emission tomography
- spinal cord
- magnetic resonance
- single cell
- patient reported outcomes
- spinal cord injury
- body composition
- hidradenitis suppurativa
- bone regeneration
- chemotherapy induced