Plasma mitochondrial DNA and metabolomic alterations in severe critical illness.
Pär I JohanssonKiichi NakahiraAngela J RogersMichael J McGeachieRebecca M BaronLaura E FredenburghJohn HarringtonAugustine M K ChoiKenneth B ChristopherPublished in: Critical care (London, England) (2018)
Differential metabolic profiles during critical illness are associated with cell-free plasma ND1 mtDNA levels that are indicative of cell damage. Elevated plasma ND1 mtDNA levels are associated with decreases in glycerophosphocholines and increases in short-chain acylcarnitines that reflect phospholipid metabolism dysregulation and decreased mitochondrial function, respectively.