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STAT3 gain of function: Too much of a good thing in the skin!

Cindy S MaStuart G Tangye
Published in: The Journal of experimental medicine (2024)
Germline activating mutations in STAT3 cause a multi-systemic autoimmune and autoinflammatory condition. By studying a mouse model, Toth et al. (https://doi.org/10.1084/jem.20232091) propose a role for dysregulated IL-22 production by Th17 cells in causing some aspects of immune-mediated skin inflammation in human STAT3 GOF syndrome.
Keyphrases
  • mouse model
  • cell proliferation
  • induced apoptosis
  • endothelial cells
  • soft tissue
  • oxidative stress
  • wound healing
  • multiple sclerosis
  • dna repair
  • drug induced
  • endoplasmic reticulum stress
  • pi k akt