Association between Acute Exposure to PM 2.5 Chemical Species and Mortality in Megacity Delhi, India.

The association between daily all-cause mortality and short-term fine particulate matter (PM 2.5 ) exposure is well established in the literature. However, association between acute exposure to PM 2.5 chemical species and mortality is not well known, especially in developing countries like India. Here we examined associations between mortality and acute exposure to PM 2.5 mass concentration and their 15 chemical components using data from 2013 to 2016 in megacity Delhi using a semiparametric quasi-Poisson regression model, adjusting for mean temperature, relative humidity, and long-term time trend as the major potential confounders. Mortality estimates were further checked for effect modification by sex, age group, and season. The subspecies of NO 3 - , NH 4 NO 3 , Cr, NH 4 + , EC, and OC showed a higher mortality impact than the total PM 2.5 mass. Males were at higher risk from NO 3 - , SO 4 2- , and their NH 4 + compounds along with carcinogen Cr, whereas female group was at higher risk from EC and OC. Among all age groups, the elderly above 65 years were the most vulnerable group prone to mortality effects from maximum species. The major mortality risk from all hazardous species arose from their winter exposures. Our study provides the first evidence of association between acute exposure to PM 2.5 chemical species and mortality anywhere in India and recommends similar studies in other regions so that sectoral mitigation emitting the most toxic species can be prioritized to maximize the health benefits.