Endothelial mineralocorticoid receptor ablation confers protection towards endothelial dysfunction in experimental diabetes in mice.

Kristina S Lyngso Boye L JensenPernille B L HansenHenrik Dimke

Published in: Acta physiologica (Oxford, England) (2021)

These findings show that endothelial cell mineralocorticoid receptor activation accounts for diabetes-induced systemic endothelial dysfunction in experimental diabetes and may explain the cardiovascular protection by MR antagonists in diabetes.

Keyphrases

type diabetes
cardiovascular disease
glycemic control
endothelial cells
drug induced
skeletal muscle
high fat diet induced
vascular endothelial growth factor
wild type