Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine.
Lorenzo LandiniDaniel Souza Monteiro de AraujoMartina ChiecaGaetano De SienaElisa BellantoniPierangelo GeppettiRomina NassiniFrancesco De LoguPublished in: Journal of biomedical science (2023)
Results suggest that, in mice, periorbital mechanical allodynia, a response that mimics cutaneous allodynia reported during migraine attacks, is elicited by ethanol via the systemic production of acetaldehyde that, by releasing CGRP, engages the CGRP receptor in Schwann cells. The ensuing cascade of intracellular events results in a Schwann cell TRPA1-dependent oxidative stress generation that eventually targets neuronal TRPA1 to signal allodynia from the periorbital area.
Keyphrases
- induced apoptosis
- neuropathic pain
- oxidative stress
- cell cycle arrest
- peripheral nerve
- spinal cord
- high fat diet induced
- endoplasmic reticulum stress
- cell death
- spinal cord injury
- single cell
- signaling pathway
- mesenchymal stem cells
- adipose tissue
- cell proliferation
- stem cells
- blood brain barrier
- metabolic syndrome
- insulin resistance
- wild type
- bone marrow
- brain injury