Connexin 43 Regulates Intercellular Mitochondrial Transfer from Human Mesenchymal Stromal Cells to Chondrocytes.

Rebecca M IrwinMatthew A ThomasMegan J FaheyMaría D MayánJames W SmythMichelle L Delco

Published in: bioRxiv : the preprint server for biology (2024)

Overexpression of GJA1-20k in MSCs increases mitochondrial transfer to chondrocytes, highlighting GJA1-20k as a potential target for promoting mitochondrial transfer from MSCs as a regenerative therapy for cartilage tissue repair in OA.

Keyphrases

mesenchymal stem cells
oxidative stress
stem cells
extracellular matrix
endothelial cells
umbilical cord
bone marrow
cell proliferation
cell therapy
knee osteoarthritis
risk assessment
tissue engineering