Regulator of G protein signaling-1 regulates immune infiltration and macrophage polarization in clear cell renal cell carcinoma.

Kun LiuDian XiaHege BianLongfei PengShuxin DaiChang LiuChao JiangYi WangJuan JinLiangkuan Bi

Published in: International urology and nephrology (2023)

RGS1 is highly expressed in ccRCC, while overexpression of RGS1 may increase immune infiltration in the TME and reduce the polarization of M2 macrophages while promoting apoptosis in ccRCC.

Keyphrases

transcription factor
oxidative stress
endoplasmic reticulum stress
cell death
cell cycle arrest