Serological biomarkers of type I, III and IV collagen turnover are associated with the presence and future progression of stricturing and penetrating Crohn's disease.
Arno R BourgonjeMarta Sorokina AlexdottirAntonius Timotheus OttenRoberta LoveikyteAnne Christine Bay-JensenMartin PehrssonHendrik M van DullemenMarijn C VisschedijkEleonora A M FestenRinse K WeersmaMorten Asser KarsdalKlaas Nico FaberJoachim Høg MortensenGerard DijkstraPublished in: Alimentary pharmacology & therapeutics (2022)
Elevated degradation of type I, III and IV collagen and excessive (relative) formation of type IV collagen strongly associates with stricturing CD. Type I and IV collagen fragments show predictive potential for the risk of penetrating disease progression. These biomarkers may become valuable tools for detection and prediction of stricturing and penetrating CD.