Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities. An Analysis from SPIROMICS.
Nirupama PutchaAshraf FawzyGabriel G PaulAllison A LambertKevin J PsoterVenkataramana K SidhayeJohn WooJ Michael WellsWassim W LabakiClaire M DoerschukRichard E KannerMeiLan K HanCarlos MartinezLaura M PaulinFernando J MartinezRobert A WiseWanda K O'NealR Graham BarrNadia N Hanselnull nullPublished in: Annals of the American Thoracic Society (2019)
Anemia is associated with worse exercise capacity, greater dyspnea, and greater disease severity among adults with COPD, particularly among those with comorbid chronic cardiac and metabolic diseases. The biomarkers found in anemic individuals suggest inflammation, lung tissue injury, and oxidative stress as possible pathways for the adverse correlations of anemia with outcomes in COPD; however, substantial further study is required to better understand these potential mechanisms. Clinical trial registered with www.clinicaltrials.gov (NCT01969344).
Keyphrases
- chronic obstructive pulmonary disease
- oxidative stress
- iron deficiency
- chronic kidney disease
- lung function
- clinical trial
- dna damage
- physical activity
- left ventricular
- emergency department
- diabetic rats
- cystic fibrosis
- type diabetes
- risk assessment
- risk factors
- climate change
- resistance training
- induced apoptosis
- open label
- human health
- atrial fibrillation
- drug induced
- weight loss