Repression of Transcriptional Activity of Forkhead Box O1 by Histone Deacetylase Inhibitors Ameliorates Hyperglycemia in Type 2 Diabetic Rats.

Hyun Min Cho Young Mi SeokHae Ahm LeeMinji SongInkyeom Kim

Published in: International journal of molecular sciences (2018)

These results indicate that HDACi attenuates the transcriptional activity of FoxO1 by impeding deacetylation, thereby ameliorating hyperglycemia in T2DM rats.

Keyphrases

diabetic rats
transcription factor
histone deacetylase
oxidative stress
gene expression
mouse model
signaling pathway
adipose tissue
skeletal muscle
cell proliferation