Targeting oxidative phosphorylation to increase the efficacy of immune-combination therapy in renal cell carcinoma.

Jihua TianJing LuoXing ZengChunjin KeYanan WangZhenghao LiuLe LiYangjun ZhangZhiquan HuChunguang Yang

Published in: Journal for immunotherapy of cancer (2024)

OXPHOS is a reliable predictor of immunotherapy response in RCC and is more pronounced in metastatic lesions. RCC cells generate a hypoxic tumor microenvironment and inhibit T-cell function through oxidative metabolism, thereby leading to immunotherapy resistance.

Keyphrases

renal cell carcinoma
combination therapy
induced apoptosis
cell cycle arrest
squamous cell carcinoma
small cell lung cancer
endoplasmic reticulum stress
cell death
signaling pathway
cell proliferation