Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging.

Husam BensretiDima W AlhamadAlejandro Marrero GonzalezManuel Pizarro-MondesirWendy B BollagCarlos M IsalesMeghan E McGee-Lawrence

Published in: Current osteoporosis reports (2022)

Harmful effects of GCs on bone mass involve several cellular pathways and events that can include BMSC differentiation bias toward adipogenesis and the influence of mature BMAT on bone remodeling through crosstalk. Interestingly, BMAT involvement remains poorly explored in GC-induced osteoporosis and warrants further investigation. This review provides an update on the current understanding of the role of glucocorticoids in the biology of osteoblasts and bone marrow adipocytes (BMAds).

Keyphrases

bone marrow
bone mineral density
postmenopausal women
adipose tissue
mesenchymal stem cells
high fat diet induced
soft tissue
bone loss
body composition
high glucose
bone regeneration
insulin resistance
type diabetes
gas chromatography