Low-dose Methotrexate Therapy Does Not Affect Semen Parameters and Sperm DNA.

Anne GrosenEmanuelle BellaguardaJacob NerstingChristian Lodberg HvasIngela Liljeqvist-SolticAdam SteinLisbet Ambrosius ChristensenEric M RudermanCalvin R BrownKjeld SchmiegelowJohn X ZhangJens KelsenStephen B Hanauer

Published in: Inflammatory bowel diseases (2021)

Patients treated with low-dose methotrexate have a sperm quality comparable with that of healthy volunteers, and methotrexate treatment does not increase sperm DNA fragmentation. This study does not support cryopreservation of semen before treatment initiation nor a 3-month methotrexate-free interval prior to conception.

Keyphrases

high dose
low dose
cell free
combination therapy
replacement therapy