Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases.
Zhi YuJin JinAdrienne TinAnna KottgenBing YuJingsha ChenAditya SurapaneniLinda ZhouChristie M BallantyneRon C HoogeveenDan E ArkingNilanjan ChatterjeeMorgan E GramsJosef CoreshPublished in: Journal of the American Society of Nephrology : JASN (2021)
A PRS for eGFR is now sufficiently strong to capture risk for a spectrum of incident kidney diseases and broadly influences the plasma proteome, primarily mediated by eGFR.