Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition.

Nezihi Murat KarabacakYu ZhengTaronish D DubashRisa BurrDouglas S Micalizzi Ben S Wittner Maoxuan LinDevon F WileyValentine ComaillsErin EmmonsKira L NiederhofferUyen HoJacob UklejaDante CheHannah Stowe Linda T NiemanWilhelm HaasShannon L StottMichael S LawrenceDavid Tsai Ting David T MiyamotoDaniel A HaberMehmet TonerShyamala Maheswaran

Published in: Cancer research (2022)

Single-cell mass cytometry analyses provide insights into the differences in kinase activities across tumor compartments and cell states, which contribute to heterogeneous responses to targeted therapies.

Keyphrases

single cell
rna seq
prostate cancer
high throughput
protein kinase
tyrosine kinase
stem cells
benign prostatic hyperplasia