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Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity.

Corina PopoviciCristina-Maria PavelValeriu SunelCorina ChepteaDan Gheorghe DimitriuDana Ortansa DorohoiDiana DavidValentina CloscaMarcel Popa
Published in: International journal of molecular sciences (2021)
Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives' applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and 1H NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against Mycobacterium tuberculosis.
Keyphrases
  • mycobacterium tuberculosis
  • healthcare
  • magnetic resonance
  • optical coherence tomography
  • mass spectrometry
  • computed tomography
  • climate change
  • pulmonary tuberculosis
  • data analysis