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Blood-brain barrier dysfunction and myelin basic protein in survival of amyotrophic lateral sclerosis with or without frontotemporal dementia.

Jin-Yue LiZheng-Yi CaiXiao-Han SunDong-Chao ShenXun-Zhe YangMing-Sheng LiuLi-Ying Cui
Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2021)
Our findings suggested that BBB dysfunction was more prominent in ALS-FTD than ALS and associated with a worse prognosis. Further studies are needed to determine the role of CSF-MBP as a biomarker in ALS.
Keyphrases
  • amyotrophic lateral sclerosis
  • blood brain barrier
  • cerebral ischemia
  • oxidative stress
  • protein protein
  • free survival
  • amino acid
  • case control