CYP2E1 plays a suppressive role in hepatocellular carcinoma by regulating Wnt/Dvl2/β-catenin signaling.

Lili ZhuXiaobei YangJingyu FengJian MaoQidong ZhangMengru HeYang MiYingwu MeiGe JinHaifeng Zhang

Published in: Journal of translational medicine (2022)

These results provide novel insight into the role of CYP2E1 in HCC and the tumor suppressor role of CYP2E1 can be attributed to its ability to manipulate Wnt/Dvl2/β-catenin pathway via inducing ROS accumulation, which provides a potential target for the prevention and treatment of HCC.

Keyphrases

stem cells
cell proliferation
dna damage
cell death
oxidative stress
risk assessment
human health
climate change