Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children.
Jessica S WallischDennis W SimonHülya BayırMichael J BellPatrick M KochanekRobert S B ClarkPublished in: Neurocritical care (2018)
In the first report of NLRP1 and NLRP3 in childhood neurotrauma, we found that CSF NLRP3 is elevated in children with severe TBI and independently associated with younger age and poor outcome. Future studies correlating NLRP3 with other markers of inflammation and response to therapy are warranted.