Interleukin-10-1082A>G (rs1800896) Single Nucleotide Polymorphism is Not a Risk Factor of Chronic Lymphocytic Leukemia in Sudanese Population.
Ameen Abdulaziz BasabaeenEnaam Abdelrhman AbdelgaderEbtihal Babekir AhmedNour Mahmoud AbdelateifSadia Osman AbdelrahimOmnia Mohamed SharifOsama Ali AltayebEman Abbass FadulIbrahim Khider IbrahimPublished in: Asian Pacific journal of cancer prevention : APJCP (2022)
Our results do not support the involvement of the IL-10 -1082A>G promoter gene polymorphism in the increased CLL susceptibility. IL-10-1082G allele (IL-10-1082AG or IL-10-1082GG) was found more frequently in males. Furthermore, no association was observed between the IL-10-1082A>G polymorphism and clinical stages systems as well as established poor prognostic markers. Finally, within the group of patients with CLL, there was no difference in the age at diagnosis and hematological parameters according to genotype distributions.