N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes.
Jérémie JoffreErika WongSamira LawtonElliot LloydNina NguyenFengyun XuCristina SempioLester KobzikIvana ZlatanovaMark SchumacherJost KlawitterHua SuKatalin RablKevin WilhelmsenChe-Chung YehJudith HellmanPublished in: Journal of neuroinflammation (2022)
OLDA has strong anti-inflammatory actions in mice with endotoxemia or S. aureus pneumonia. Prior studies focused on the role of peripheral nervous system TRPV1 in modulating inflammation and pneumonia. Our results suggest that TRPV1-expressing central nervous system neurons also regulate inflammatory responses to endotoxemia and infection. Our study reveals a neuro-immune reflex that during acute inflammation is engaged proximally by OLDA acting on neuronal TRPV1, and through a multicellular network that requires circulating monocytes/macrophages, leads to the systemic production of IL-10.
Keyphrases
- neuropathic pain
- oxidative stress
- respiratory failure
- lps induced
- anti inflammatory
- spinal cord
- liver failure
- cerebrospinal fluid
- acute kidney injury
- drug induced
- signaling pathway
- spinal cord injury
- inflammatory response
- adipose tissue
- extracorporeal membrane oxygenation
- community acquired pneumonia
- high fat diet induced
- metabolic syndrome
- hepatitis b virus
- case control
- acute respiratory distress syndrome
- aortic dissection
- blood brain barrier