Bushen Huoxue Recipe inhibits endometrial epithelial-mesenchymal transition through the transforming growth factor-β/nuclear factor kappa-B pathway to improve polycystic ovary syndrome-mediated infertility.
Hanxue WuPeijuan WuYing ZhuJunjie LiHaiyan ChenHongqiu ZhuPublished in: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2024)
TGF-β, TAK1, NF-κB, and TNF-α are important targets of BSHX for treating infertility in PCOS. BSHX improves the inflammatory state of PCOS, intervenes in the endometrial EMT process through the TGF-β/NF-κB pathway, and restores endometrial pathological changes, further improving the pregnancy outcome in PCOS.
Keyphrases
- polycystic ovary syndrome
- transforming growth factor
- nuclear factor
- epithelial mesenchymal transition
- toll like receptor
- insulin resistance
- signaling pathway
- endometrial cancer
- rheumatoid arthritis
- oxidative stress
- preterm birth
- adipose tissue
- skeletal muscle
- pi k akt
- inflammatory response
- type diabetes
- immune response
- pregnancy outcomes