Characterization of myocardial mechanics and its prognostic significance in patients with severe aortic stenosis undergoing aortic valve replacement.
Xiaojun BiDarwin F YeungJeremy J ThadenLara F NholaHartzell V SchaffSorin V PislaruPatricia A PellikkaAlberto PochettinoKevin L GreasonVuyisile T NkomoHector R VillarragaPublished in: European heart journal open (2022)
In patients with severe AS, a reversal in GLS, apical rotation, and peak systolic twist abnormalities towards normal occurs within days of AVR. Baseline GLS is the strongest predictor of GLS recovery but neither was associated with long-term survival. In contrast, abnormal baseline GCSRs are associated with worse outcomes.
Keyphrases
- aortic stenosis
- aortic valve replacement
- left ventricular
- transcatheter aortic valve implantation
- transcatheter aortic valve replacement
- aortic valve
- ejection fraction
- early onset
- heart failure
- coronary artery disease
- magnetic resonance
- blood pressure
- epithelial mesenchymal transition
- drug induced
- computed tomography
- type diabetes
- adipose tissue
- insulin resistance
- signaling pathway
- magnetic resonance imaging