Unpacking the Pathogen Box-An Open Source Tool for Fighting Neglected Tropical Disease.
Clinton G L VealePublished in: ChemMedChem (2019)
The Pathogen Box is a 400-strong collection of drug-like compounds, selected for their potential against several of the world's most important neglected tropical diseases, including trypanosomiasis, leishmaniasis, cryptosporidiosis, toxoplasmosis, filariasis, schistosomiasis, dengue virus and trichuriasis, in addition to malaria and tuberculosis. This library represents an ensemble of numerous successful drug discovery programmes from around the globe, aimed at providing a powerful resource to stimulate open source drug discovery for diseases threatening the most vulnerable communities in the world. This review seeks to provide an in-depth analysis of the literature pertaining to the compounds in the Pathogen Box, including structure-activity relationship highlights, mechanisms of action, related compounds with reported activity against different diseases, and, where appropriate, discussion on the known and putative targets of compounds, thereby providing context and increasing the accessibility of the Pathogen Box to the drug discovery community.
Keyphrases
- drug discovery
- transcription factor
- dengue virus
- candida albicans
- binding protein
- zika virus
- climate change
- structure activity relationship
- systematic review
- mental health
- healthcare
- mycobacterium tuberculosis
- machine learning
- emergency department
- hepatitis c virus
- aedes aegypti
- adverse drug
- hiv aids
- drug induced
- deep learning
- pulmonary tuberculosis
- hiv infected
- human immunodeficiency virus
- electronic health record