Dexmedetomidine postconditioning attenuates myocardial ischemia/reperfusion injury by activating the Nrf2/Sirt3/SOD2 signaling pathway in the rats.

Bin Hu Tian Tian Xin-Tao Li Pei-Pei Hao Wei-Chao Liu Ying-Gui Chen Tian-Yu Jiang Pei-Shan Chen Yi Cheng Fu-Shan Xue

Published in: Redox report : communications in free radical research (2023)

Dex postconditioning can alleviate myocardial IRI by suppressing oxidative stress and apoptosis, and these beneficial effects are at least partly mediated by activating the Nrf2/Sirt3/SOD2 signaling pathway.

Keyphrases

oxidative stress
signaling pathway
ischemia reperfusion injury
pi k akt
induced apoptosis
left ventricular
epithelial mesenchymal transition
diabetic rats
amyotrophic lateral sclerosis
dna damage
cell cycle arrest
cerebral ischemia
cardiac surgery
heat shock
cell proliferation