Antimicrobial sesquiterpene lactones from Artemisia sieberi.
Tarik A MohamedMohamed-Elamir F HegazyAbeer A Abd El AtyHazem A GhabbourMansour S AlsaidAbdelaaty A ShahatPaul W ParéPublished in: Journal of Asian natural products research (2017)
Two new sesquiterpene lactones 3R, 8R-dihydroxygermacr-4(15),9(10)-dien-6S,7S,11RH,12,6-olide (1) and 1R, 8S-dihydroxy-11R,13-dihydrobalchanin(2), together with two known compounds 11-epiartapshin (3) and 3'-hydroxygenkwanin (4), were isolated from Artemisia sieberi. Their structures were elucidated by 1D, 2D NMR, MS, and X-ray diffraction. Compound 4 inhibited Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus with Minimal inhibitory concentration values of 50 and 25 μg/disk, respectively. All the isolated compounds exhibited moderate antifungal activities.
Keyphrases
- bacillus subtilis
- staphylococcus aureus
- high resolution
- mass spectrometry
- magnetic resonance
- biofilm formation
- candida albicans
- multiple sclerosis
- gram negative
- ms ms
- electron microscopy
- methicillin resistant staphylococcus aureus
- solid state
- escherichia coli
- magnetic resonance imaging
- cystic fibrosis
- crystal structure
- contrast enhanced