Login / Signup

RNA-Binding Proteins Regulate Post-Transcriptional Responses to TGF-β to Coordinate Function and Mesenchymal Activation of Murine Endothelial Cells.

Rhys WardmanMerve KelesIhor PachkivShruthi HemannaSteve GreinJennifer J SchwarzFrank SteinRoxana OlaGergana DobrevaMatthias W HentzeJoerg Heineke
Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Together, we show that RBPs play a key role in the endothelial response to TGF-β stimulation at the post-transcriptional level and that the RBPs hnRNP H1 and Csde1 serve to maintain EC function and counteract mesenchymal activation. We propose that TGF-β profoundly modifies RNA-protein interaction entailing feedback and feed-forward control at the post-transcriptional level, to fine-tune mesenchymal activation in ECs.
Keyphrases
  • endothelial cells
  • bone marrow
  • transforming growth factor
  • stem cells
  • gene expression
  • transcription factor
  • heat shock
  • air pollution
  • epithelial mesenchymal transition
  • signaling pathway
  • high glucose