Apoptosis Induced by Prednisolone Occurs without Altering the Promoter Methylation of BAX and BCL-2 Genes in Acute Lymphoblastic Leukemia Cells CCRF-CEM.
Saiedeh GanbarjeddiAko AzimiMilad Zadi HeydarabadMaryam HemmatzadehShahin MohammadiReza Mousavi ArdehaieMajid ZamaniSina BaharaghdamSajjad EsmaeiliAmin GhasemiPublished in: Asian Pacific journal of cancer prevention : APJCP (2020)
Lack of alteration through prednisolone treatment in DNA methylation template of BAX and BCL2 genes make this possible that Prednisolone affects apoptotic gene expression via different pathways, which need more research to be done about it.<br />.
Keyphrases
- dna methylation
- genome wide
- induced apoptosis
- gene expression
- endoplasmic reticulum stress
- cell cycle arrest
- acute lymphoblastic leukemia
- cell death
- oxidative stress
- signaling pathway
- copy number
- pi k akt
- genome wide identification
- allogeneic hematopoietic stem cell transplantation
- transcription factor
- smoking cessation