A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: a feasibility randomized clinical trial.

Timm GreulichJens M HohlfeldPetra NeuserKatrin LueerAndreas KlemmerCarmen Schade-BrittingerSusanne HarnischHolger GarnHarald RenzUrsula HomburgJonas RenzAnne KirstenFrauke PedersenMeike MüllerClaus F VogelmeierHenrik Watz

Published in: Respiratory research (2018)

In patients with eosinophilic COPD, sputum eosinophils could be reduced by inhalation of SB010. Long-term studies are needed to demonstrate clinical efficacy.

Keyphrases

chronic obstructive pulmonary disease
cystic fibrosis
end stage renal disease
mycobacterium tuberculosis
lung function
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
chronic rhinosinusitis
patient reported outcomes
air pollution
single molecule