Development and validation of a high-performance thin-layer chromatography method for detection of sibutramine in dietary supplements.
Vanya Rangelov KozhuharovDzhevdet ChakarovStanislava IvanovaKalin IvanovPublished in: Folia medica (2024)
In the period between 1997 and 2010, sibutramine-containing drugs were widely prescribed for obesity and over-weight management. Due to safety concerns, in 2010 all medicines containing sibutramine were urgently withdrawn from the USA and European pharmaceutical market. Although sibutramine is no longer available in pharmaceutical products, there have been numerous reports of mislabeled weight-loss dietary supplements containing sibutramine.
Keyphrases
- weight loss
- bariatric surgery
- roux en y gastric bypass
- weight gain
- gastric bypass
- metabolic syndrome
- type diabetes
- mass spectrometry
- insulin resistance
- body mass index
- emergency department
- health insurance
- tandem mass spectrometry
- adipose tissue
- high fat diet induced
- high resolution
- liquid chromatography
- quantum dots
- high performance liquid chromatography
- label free
- ms ms