High-Flow Oxygen and High-Flow Air for Dyspnea in Hospitalized Patients with Cancer: A Pilot Crossover Randomized Clinical Trial.

David HuiFarley HernandezDiana UrbauerSaji ThomasZhanni LuAhmed ElsayemEduardo Bruera

Published in: The oncologist (2020)

This double-blind, 4×4 crossover trial examined the effect of oxygen or air delivered at high- or low-flow rates on dyspnea in hospitalized nonhypoxemic patients with cancer. High-flow oxygen and high-flow air were significantly better at reducing dyspnea than low-flow oxygen/air, supporting a role for palliation beyond oxygenation.

Keyphrases

double blind
placebo controlled
study protocol
clinical trial
phase iii
open label
palliative care