Light-activated drug release from prodrug nanoassemblies by structure destruction.

Yang LiShujuan WangYulan HuangYuwen ChenWenbi WuYu LiuJing ZhangYue FengXian JiangMaling Gou

Published in: Chemical communications (Cambridge, England) (2019)

We report here a novel light-triggered nanosystem based on co-assembling nanoaggregates (NAs) of lipophilic photosensitizers and lipophilic prodrugs containing multiple thioethers. Upon laser irradiation, the oxidization of the multiple thioethers by photosensitizer-generated singlet oxygen could rapidly destroy the NA structure, resulting in faster drug release than those containing a single thioether.

Keyphrases

drug release
photodynamic therapy
drug delivery
cancer therapy
radiation induced
mass spectrometry
quantum dots
energy transfer