Diastereoselective synthesis of trifluoromethylated 1,3-dioxanes by intramolecular oxa-Michael reaction.

Liliana Becerra-FigueroaElodie BrunMichael MathiesonLouis J FarrugiaClaire WilsonJoëlle PrunetDiego Gamba-Sánchez

Published in: Organic & biomolecular chemistry (2018)

A highly diastereoselective synthesis of trifluoromethylated 1,3-dioxanes is described. The reaction proceeds by an addition/oxa-Michael sequence and works efficiently under mild reaction conditions, with a good substrate scope and acceptable to good yields.

Keyphrases

acinetobacter baumannii
klebsiella pneumoniae
electron transfer
amino acid
escherichia coli
cystic fibrosis