Spatiotemporal depletion of tumor-associated immune checkpoint PD-L1 with near-infrared photoimmunotherapy promotes antitumor immunity.

Shunichi TakiKohei MatsuokaYuko NishinagaKazuomi TakahashiHirotoshi YasuiChiaki KoikeMisae ShimizuMitsuo SatoKazuhide Sato

Published in: Journal for immunotherapy of cancer (2021)

Local PD-L1-targeted NIR-PIT enhanced the antitumor immune reaction through a direct photonecrotic effect, thereby providing an alternative approach to targeted cancer immunotherapy and expanding the scope of cancer therapeutics.

Keyphrases

cancer therapy
papillary thyroid
small molecule
drug release
fluorescence imaging
drug delivery
lymph node metastasis
young adults
fluorescent probe