Spatiotemporal depletion of tumor-associated immune checkpoint PD-L1 with near-infrared photoimmunotherapy promotes antitumor immunity.
Shunichi TakiKohei MatsuokaYuko NishinagaKazuomi TakahashiHirotoshi YasuiChiaki KoikeMisae ShimizuMitsuo SatoKazuhide SatoPublished in: Journal for immunotherapy of cancer (2021)
Local PD-L1-targeted NIR-PIT enhanced the antitumor immune reaction through a direct photonecrotic effect, thereby providing an alternative approach to targeted cancer immunotherapy and expanding the scope of cancer therapeutics.