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Expedited liver transplantation as first-line therapy for severe alcohol hepatitis: ELFSAH; deferring corticosteroids in the sickest subset of patients.

Nabeeha Mohy-Ud-DinFei-Pi LinVikrant RachakondaAli Al-KhafajiScott W BigginsSwaytha GaneshRamon BatallerAndrea DiMartiniChristopher HughesAbhinav HumarShahid M Malik
Published in: Clinical transplantation (2024)
We propose ELFSAH: Expedited LT as First Line Therapy for SAH; challenging the current paradigm with recommendations to defer steroids in patients with "catastrophic" SAH (defined as: MELD-Na ≥35 and/or DF ≥100). Patients should be seen urgently by hepatology, transplant surgery, psychiatry and social work. Patients without an absolute contraindication should be referred for LT as first-line therapy during their index admission.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • healthcare
  • mental health
  • stem cells
  • patient reported outcomes
  • coronary artery disease
  • early onset
  • atrial fibrillation
  • cell therapy