Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax.

Masahiro YamamotoTomomi SanomachiShuhei SuzukiKeita TogashiAsuka SugaiShizuka SeinoAtsushi SatoMasashi OkadaChifumi Kitanaka

Published in: Neuro-oncology advances (2021)

These results not only indicate the potential of gemcitabine as a candidate radiosensitizer for malignant meningioma, but also reveal a novel role for gemcitabine radiosensitization as a means to create a therapeutic vulnerability of senescent meningioma cells to senolytics.

Keyphrases

induced apoptosis
cell cycle arrest
locally advanced
optic nerve
endoplasmic reticulum stress
oxidative stress
squamous cell carcinoma
signaling pathway
genome wide
risk assessment
rectal cancer