Bleeding and thrombotic risk in pregnant women with Fontan physiology.
Andrea GirniusDominica ZentnerAnne Marie ValentePetronella G PieperKatherine E EconomyMagalie LadouceurJolien W Roos-HesselinkCarri WarshakSara L PartingtonZhiqian GaoNicholas OllberdingMichelle FaustSaulius GirniusHarald KaemmererNicole NagdymanScott CohenMary CanobbioTeiji AkagiJasmine GrewalElisa BradleyYonathan BuberJoseph PalumboNiki WalkerJamil AboulhosnErwin OechslinHelmut BaumgartnerWesam KurdiWendy M BookBarbara J M MulderGruschen R VeldtmanPublished in: Heart (British Cardiac Society) (2020)
Current antithrombotic strategies appear effective at attenuating thrombotic risk in pregnant women with a Fontan. However, this comes with high (>30%) bleeding risk, of which 13% are life threatening. Achieving haemostatic balance is challenging in pregnant women with a Fontan, necessitating individualised risk-adjusted counselling and therapeutic approaches that are monitored during the course of pregnancy.