Mitochondrial fumarate promotes ischemia/reperfusion-induced tubular injury.

Zuo-Lin LiMing-Min HuangMeng-Yao YuDi-Fei NieSha-Li FuJing-Jing DiTing LanBi-Cheng LiuQiu-Li Wu

Published in: Acta physiologica (Oxford, England) (2024)

Our studies demonstrated that the mitochondrial-derived fumarate promotes tubular epithelial cell injury in renal I/RI. Blockade of fumarate-mediated ROS/NF-κB signaling activation may serve as a novel therapeutic approach to ameliorate hypoxic tubule injury.

Keyphrases

high glucose
oxidative stress
signaling pathway
diabetic rats
drug induced
toll like receptor