Patient-derived organoids reflect the genetic profile of endometrial tumors and predict patient prognosis.

Hege F BergMarta Espevold HjelmelandHilde LienHeidi EspedalTina FonnesAashish Srivastava Tomasz Stokowy Elin Strand Olivera BozickovicIngunn M StefanssonLine BjørgeJone TrovikIngfrid S HaldorsenErling A Hoivik Camilla Krakstad

Published in: Communications medicine (2021)

We establish robust model systems that capture both the diversity of endometrial tumors and intra-tumor heterogeneity. These models are highly relevant preclinical tools for the elucidation of the molecular pathogenesis of EC and identification of potential treatment strategies.

Keyphrases

endometrial cancer
case report
single cell
genome wide
gene expression
single molecule
stem cells
dna methylation
climate change